Auflistung nach Autor "D'Auria, John C."
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Biochemical studies in the elucidation of genes involved in tropane alkaloid production in Erythroxylum coca and Erythroxylum novogranatense
Estrada, Olga P. (2017-05)Natural products are vastly used in the modern pharmacopoeia. Among the most abundant natural products in medicine, there are tropane and granatane alkaloids. Efforts in the investigation of tropane and granatane biosynthesis ... -
Elucidation of novel N-methyltransferases in tropane and granatane alkaloid biosynthesis
Anderson, Kayla Nicole; 0000-0003-2406-532X (2019-08)Alkaloids are specialized metabolites produced by plants to protect themselves from biotic and abiotic forces. Tropane and granatane alkaloids are of special importance due to their vast pharmacological benefits. The ... -
Mechanism-based inhibition of ergosterol biosynthesis in Acanthamoeba castellanii and its therapeutic implications
Thomas, Crista D.; 0000-0003-1795-3767 (2016-12-07)In this study we investigate the amoebacidal activity of 10 steroidal inhibitors which block sterol C24-methylation, and compare its efficacy to 5 medical azoles which block sterol C14-demethylation, against Acanthamoeba ... -
Mre11 mutants affect the activity of Mre11-Rad50-Nbs1/Xrs2 complex and the DNA double strand break repair pathway
Rahman, Samiur; 0000-0002-4420-9469 (2021-05)The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process ... -
The influence of hairy root cultures on the biosynthesis of granatane alkaloids in Punica granatum (pomegranate)
Glockzin, Kyle Mark (2019-08)There is a fundamental lack of knowledge of the biosynthetic steps and the kinetic properties of the enzymes that catalyze the reactions that make tropane and granatane alkaloids. The synthetic biology and metabolic ... -
Tropane alkaloid biosynthesis in Erythroxylum coca involves an atypical type III polyketide synthase
Kim, Neill; 0000-0001-7917-8343 (2020-05)Alkaloids represent 20% of all specialized metabolites. These important compounds are produced by plants to protect themselves from biotic or abiotic forces they may encounter. Tropane alkaloids and granatane alkaloids ...