Browsing by Department "HSC - Pharmaceutical Sciences"
Now showing items 1-4 of 4
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Capecitabine in the treatment of brain metastases of breast cancer: Critical role of enzymatic targeting of key metabolic species
(2015-05)Breast cancer brain metastases (BCBM) are a grave health problem with limited therapeutic options because of poor drug delivery. Capecitabine, an enzymatically targeted prodrug of 5-fluorouracil (5-FU), shows promise in ... -
Diet and exercise as potential anticonvulsant therapies in mouse seizure models
(2016-05)Non-pharmacological therapies can potentially provide seizure relief in patients with drug resistant epilepsy. This research used diet and exercise to modulate metabolism, hypothesizing that enhancement of oxidative ... -
Prostate cancer intervention by methylseleninic acid: Strengthening a case for human translation
(2016-05)Clinical trials with seleno-methionine (SeMet) and selenized yeast for prostate cancer prevention in North America conclusively rejected these selenium (Se) forms for prevention in men who were Se-proficient. Nevertheless, ... -
Toxicological impact of tobacco smoke exposure on blood brain barrier endothelium: Pathophysiological implications and cytoprotective mechanisms
(2015-05)Despite the strong evidence for an association between tobacco smoke (TS) and vascular impairment, the impact of TS exposure on the blood brain barrier (BBB) endothelium has been only marginally addressed. Moreover, several ...