Origins of linkage models

Abstract

The purpose of this thesis is to offer a concise historical account of the origins of linkage analysis. The time frame of the thesis ranges from the rediscovery of Mendel's paper in 1900 to topics of interest during the late 1930's. The analysis is done through a mathematical perspective. Topics include the detection of linkage, estimations of linkage and early discussions of the mechanism by which linked genetic material was inherited.