Zur Kurzanzeige

dc.creatorMosher, Michael D.
dc.date.available2011-02-18T21:16:01Z
dc.date.issued1993-08
dc.identifier.urihttp://hdl.handle.net/2346/15818en_US
dc.description.abstractThe goals of the research described in this dissertation were to study the palladium-mediated intramolecular nucleometallatlon/methoxycarbonylation of yoxoallenes (see Scheme 1) and to use the methyl furanoside products obtained from such reactions in the syntheses of deoxy- and dideoxyribonucleoside analogues. Nucleoside analogues are currently of particular interest due to their ability to act as anti-tumor and anti-AIDS (Acquired Immunodeficiency Syndrome) medicines. A section of this introduction has been dedicated to information about AIDS and antiretrovlral nucleoside analogues. A convenient route to enantiomerically pure C-nucleoslde derivatives will be mentioned as a side project. (C-Nucleosides have also been found to possess potent biological activity). In addition, the cyclizatlon of 4,5-hexadienoic acid to give butyrolactone products will be described (see Scheme 1; R'" = OH).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherTexas Tech Universityen_US
dc.subjectPalladium catalystsen_US
dc.subjectAllene -- Synthesisen_US
dc.subjectNucleic acids -- Synthesisen_US
dc.titlePalladium-mediated cyclizations of gamma-oxoallenes: synthesis of structurally modified nucleic acids
dc.typeDissertation
thesis.degree.namePh.D.
thesis.degree.levelDoctoral
thesis.degree.disciplineChemistry
thesis.degree.grantorTexas Tech University
thesis.degree.departmentChemistry
thesis.degree.departmentChemistry and Biochemistry
dc.degree.departmentChemistryen_US
dc.rights.availabilityUnrestricted.


Dateien zu dieser Ressource

Thumbnail

Das Dokument erscheint in:

Zur Kurzanzeige