Modeling and optimization of heparinized collagenous surfaces

Abstract

The primary objective of this research is to determine the optimal conditions of heparin immobilization on collagen powder by varying pretreatment methods, pH of reaction environment and l-ethyl-3(3-dimethylaminopropyl) carbodiimide (i.e., EDC) to heparin weight ratio. This research is part of a series of investigations, of which the ultimate purpose is to develop an implantable small diameter (less than 6 mm diameter) (Parsonnet, 1976) vascular prosthesis which will remain functional while serving as a suitable interposition in the circulatory system.