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Rational design and syntheis of substrate-based inhibitors of steroidogenesis
(Texas Tech University, 2008-12)
Sterol biosynthesis is crucial to all groups of life forms. Targeted inhibition of this pathway by substrate-based analogs is currently used to probe sterol function and may have therapeutic importance. In this dissertation, ...
Fast data analysis framework for scientific big data applications
Scientific breakthroughs are increasingly powered by advanced computing and data analysis capabilities. The data-driven scientific discovery has become the new fourth paradigm of scientific innovation after theory, experiment, ...
Synthesis and testing of sterol biosynthesis inhibitors with Candida albicans
(Texas Tech University, 2002-12)
A series of lanosterol analogs which contain a heteroatom substituted for C-24 or C-25 or otherwise modified in the double bond character in the sterol side chain at C-24 (25) have been prepared and assayed with Candida ...