The circulatory levels of irisin in response to acute and chronic resistance training in healthy humans
Short, Matthew James
MetadataShow full item record
Obesity is a growing problem in the U.S. and worldwide. Research for potential treatments is abounding. One potential cytokine of interest for the treatment of obesity is irisin. Irisin is released by muscle during physical activity and increases the browning of beige and brown adipocytes. We recruited 31 young and healthy adult males and females (20 female; 11 male) subjects. After blocking and randomly assigning the subjects to either a non-exercise control or exercise intervention group, we analyzed 8 control subjects and 10 exercise intervention subjects after a single bout of high-intensity exercise training. After a 3-week intervention of high intensity resistance training, we analyzed 7 control and 7 exercise intervention subjects. The acute intervention resulted in a significant decreased irisin level during, but not after, an exercise session for the exercise group. The chronic intervention resulted in significant changes in body composition and in an increase in upper and lower body strength in the exercise group. No increase of circulatory irisin was found after 3 weeks of high-intensity exercise training.