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dc.creatorServati, Mahsa
dc.date.accessioned2018-09-05T18:43:18Z
dc.date.available2018-09-05T18:43:18Z
dc.date.created2018-08
dc.date.issued2018-08
dc.date.submittedAugust 2018
dc.identifier.urihttp://hdl.handle.net/2346/74527
dc.description.abstractSeveral potential mechanisms of mechanical coordination of the constriction of the cell apices in groups of cells have been proposed. Our previous computational studies have shown a connection between tensile mechanical feedback and Cellular Constriction Chains (CCCs) that propagate during the first phase of Ventral Furrow Formation (VFF) in the Drosophila melanogaster embryo. Detailed imaging of the underside of the embryo allows us to analyze how morphological aspects of cell clusters change over time. We have used confocal microscopy to take high-resolution time-lapsed images of living Spider GFP embryos, mutants that have Green Fluorescence Protein (GFP) embedded in their cell membranes. Monitoring the progression of individual cell shapes through image analysis, we have explored nature of mechanical coordination responsible and established a method for evaluating the underlying cause of cellular group formations.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.subjectDrosophila
dc.subjectApical constriction
dc.subjectSoft condensed matter
dc.subjectConfocal imaging
dc.titleImaging Drosophila embryo gastrulation to identify stress fields and biomechanical feedback
dc.typeThesis
dc.date.updated2018-09-05T18:43:18Z
dc.type.materialtext
thesis.degree.nameMaster of Science
thesis.degree.levelMasters
thesis.degree.disciplinePhysics
thesis.degree.grantorTexas Tech University
thesis.degree.departmentPhysics
dc.contributor.committeeMemberThomas, Jeffery H.
dc.contributor.committeeMemberSanati, Mahdi
dc.contributor.committeeChairBlawzdziewicz, Jerzy
dc.rights.availabilityRestricted from online display. For access, please request a copy.
dc.creator.orcid0000-0002-1420-5926


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