Vascular remodeling is associated with increased permeability of experimental brain metastases of breast cancer

Abstract

[From Chapter 1] In summary, this dissertation is a quantitative evaluation of the vascularity and/or angiogenesis involved in the altered permeability of brain metastases of breast cancer. The data suggest that multiple mechanisms play a role in altering the integrity of the BTB. Our data also illuminate the role of bevacizumab in the decreased efficacy of chemotherapeutics during combinatorial therapy in experimental brain metastases of breast cancer. Lastly, our data point to an exciting novel combination therapy that may significantly decrease the formation of brain metastases of breast cancer.