Effect of Thermal Gradients Created by Electromagnetic Fields on Cell-Membrane Electroporation Probed by Molecular-Dynamics Simulations

Date

2017

Journal Title

Journal ISSN

Volume Title

Publisher

American Physical Society

Abstract

The use of nanosecond-duration-pulsed voltages with high-intensity electric fields (∼100 kV/cm) is a promising development with many biomedical applications. Electroporation occurs in this regime, and has been attributed to the high fields. However, here we focus on temperature gradients. Our numerical simulations based on molecular dynamics predict the formation of nanopores and water nanowires, but only in the presence of a temperature gradient. Our results suggest a far greater role of temperature gradients in enhancing biophysical responses, including possible neural stimulation by infrared lasers.

Description

© 2017 American Physical Society

Keywords

Biological Physics, Biomolecular Dynamics, Cell Membrane Transport, Electrophoresis, Laser Applications, Medical Physics, Membranes, Transport Phenomena

Citation

J. Song, A. L. Garner, and R. P. Joshi, "Effects of Thermal Gradients Created by Electromagnetic Fields on Cell Membrane Electroporation Probed by Molecular Dynamics Simulations," Physical Review Applied 7, 024003 (2017). https://doi.org/10.1103/PhysRevApplied.7.024003

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