Comparative evaluation of transmembrane ion transport due to monopolar and bipolar nanosecond, high-intensity electroporation pulses based on full three-dimensional analyses

Date

2017

Journal Title

Journal ISSN

Volume Title

Publisher

AIP

Abstract

Electric pulse driven membrane poration finds applications in the fields of biomedical engineering and drug/gene delivery. Here we focus on nanosecond, high-intensity electroporation and probe the role of pulse shape (e.g., monopolar-vs-bipolar), multiple electrode scenarios, and serial-versus-simultaneous pulsing, based on a three-dimensional time-dependent continuum model in a systematic fashion. Our results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction is in agreement with experimental reports and observations. It is also demonstrated that multi-pronged electrode configurations influence and increase the degree of cellular uptake.

Description

This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.

Keywords

Cellular Uptake, Nanomaterials, Gene Delivery, Electroporation, Cell Membranes, Electrochemistry, Chemical Elements, Sequence Analysis, Electrolytes, Biomedical Engineering

Citation

Q. Hu and R. P. Joshi, "Comparative evaluation of transmembrane ion transport due to monopolar and bipolar nanosecond, high-intensity electroporation pulses based on full three-dimensional analyses," Journ. Appl. Phys. 122, 034701 (2017). https://doi.org/10.1063/1.4994310

Collections