Synthesis and metal ion sorption by proton-ionizable, acyclic and cyclic polyether resins
Laney, Evelyn E.
MetadataShow full item record
In 1967 Pedersen published the first of four fundamental papers on the synthesis and properties of macrocyclic polyether compounds. 1 "4 This class of compounds was discovered by accident during the preparation of bis-(<9-hydroxyphenoxy)ethyl ether (1) by reaction of bis chloroethyl) ether with the sodium salt of o-hydroxyphenoxytetrahydropyran followed by acid hydrolysis. Along with the anticipated product 1, Pedersen isolated a small quantity of a by-product. Investigation into the structure of the byproduct identified the compound as macrocyclic polyether 2 which was formed by the cyclic condensation of 2 moles of unprotected catechol, a small amount of which was present in the reactant, with 2 moles of bis(chloroethyl) ether.