Show simple item record

dc.creatorMcGilvray, Whitney D.
dc.creatorJohnson, Bradley J.
dc.creatorWooten, Hailey
dc.creatorRakhshandeh, Amanda R.
dc.date.accessioned2021-08-26T15:36:47Z
dc.date.available2021-08-26T15:36:47Z
dc.date.issued2019
dc.identifier.citationMcGilvray WD, Johnson B, Wooten H, Rakhshandeh AR, Rakhshandeh A. Immune System Stimulation Reduces the Efficiency of Whole-Body Protein Deposition and Alters Muscle Fiber Characteristics in Growing Pigs. Animals. 2019; 9(6):323. https://doi.org/10.3390/ani9060323en_US
dc.identifier.urihttps://doi.org/10.3390/ani9060323
dc.identifier.urihttps://hdl.handle.net/2346/87762
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.description.abstractThe effects of immune system stimulation (ISS), induced by repeated injection of Escherichia coli lipopolysaccharide, on the whole-body protein synthesis versus degradation rates, the efficiency of protein deposition (PD), and muscle fiber characteristics in pigs were evaluated. Twelve growing gilts were assigned to two levels of amino acid intake that was predicted based on the potential of each group’s health status for PD and feed intake. Isotope tracer, nitrogen balance, and immunohistochemical staining techniques were used to determine protein turnover, PD, and muscle fiber characteristics, respectively. Protein synthesis, degradation, and PD were lower in immune-challenged pigs than in control pigs (p < 0.05). Strong tendencies for a higher protein synthesis-to-PD ratio (p = 0.055) and a lower protein synthesis-to-degradation ratio (p = 0.065) were observed in immune-challenged pigs. A decrease in muscle cross-sectional area of fibers and a shift from myosin heavy chain (MHC)-II towards MHC-I fibers (p < 0.05) were observed in immune-challenged pigs. These results indicated that ISS reduces PD not only by suppressing the whole-body protein synthesis and degradation rates, but also by decreasing the efficiency of PD in growing pigs. In addition, ISS induces atrophy in skeletal muscles and favors a slow-twitch oxidative fiber type composition.en_US
dc.language.isoengen_US
dc.subjectImmune System Simulationen_US
dc.subjectMuscle Fibersen_US
dc.subjectPigsen_US
dc.subjectProtein Turnoveren_US
dc.titleImmune System Stimulation Reduces the Efficiency of Whole-Body Protein Deposition and Alters Muscle Fiber Characteristics in Growing Pigsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record