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dc.creatorMullins, Caitlyn (TTU)
dc.creatorGannaban, Ritchel B. (TTU)
dc.creatorKhan, Md Shahjalal (TTU)
dc.creatorShah, Harsh (TTU)
dc.creatorSiddik, Md (TTU)
dc.creatorHegde, Vijay (TTU)
dc.creatorReddy, P. Hemachandra (TTUHSC)
dc.creatorShin, Andrew C. (TTU)
dc.date.accessioned2022-05-12T21:02:03Z
dc.date.available2022-05-12T21:02:03Z
dc.date.issued2020
dc.identifier.citationMullins CA, Gannaban RB, Khan MS, Shah H, Siddik MAB, Hegde VK, Reddy PH, Shin AC. Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain. Antioxidants. 2020; 9(10):1018. https://doi.org/10.3390/antiox9101018en_US
dc.identifier.urihttps://doi.org/10.3390/antiox9101018
dc.identifier.urihttps://hdl.handle.net/2346/89187
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.description.abstractObesity prevalence is increasing at an unprecedented rate throughout the world, and is a strong risk factor for metabolic, cardiovascular, and neurological/neurodegenerative disorders. While low-grade systemic inflammation triggered primarily by adipose tissue dysfunction is closely linked to obesity, inflammation is also observed in the brain or the central nervous system (CNS). Considering that the hypothalamus, a classical homeostatic center, and other higher cortical areas (e.g. prefrontal cortex, dorsal striatum, hippocampus, etc.) also actively participate in regulating energy homeostasis by engaging in inhibitory control, reward calculation, and memory retrieval, understanding the role of CNS oxidative stress and inflammation in obesity and their underlying mechanisms would greatly help develop novel therapeutic interventions to correct obesity and related comorbidities. Here we review accumulating evidence for the association between ER stress and mitochondrial dysfunction, the main culprits responsible for oxidative stress and inflammation in various brain regions, and energy imbalance that leads to the development of obesity. Potential beneficial effects of natural antioxidant and anti-inflammatory compounds on CNS health and obesity are also discussed.en_US
dc.language.isoengen_US
dc.subjectAntioxidantsen_US
dc.subjectAnti-Inflammatory Agentsen_US
dc.subjectHypothalamusen_US
dc.subjectHippocampusen_US
dc.subjectPrefrontal Cortexen_US
dc.subjectER Stressen_US
dc.subjectMitochondrial Dysfunctionen_US
dc.titleNeural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brainen_US
dc.typeArticleen_US


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