Monte Carlo Expectation-Maximization algorithm to detect imprinting and maternal effects for discordant sib-pair data
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Abstract
Numerous statistical methods have been developed to explore genomic imprinting and maternal effects, which are causes of parent-of-origin patterns in complex human diseases. However, most of them either only model one of these two confounded epigenetic effects, or make strong yet unrealistic assumptions about the population to avoid over- parameterization. A recent partial likelihood method (