Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.)

Abstract

Achillea fragrantissima is a perennial herb grown in Egypt and traditionally employed medicinally for its anti-inflammatory and analgesic properties among Sinai inhabitants. Non-polar and polar extracts were obtained by successive foliar extraction with dichloromethane:methanol (1:1) and 70% aqueous methanol, respectively. Achillea extracts were assayed in rodents for anti-inflammatory, anti-ulcerogenic and analgesic activities. Materials and methods: Acute toxicity of non-polar and polar extracts of A. fragrantissima was evaluated in mice. Anti-inflammatory activity was assessed in carrageenan-induced rat-paw edema test while analgesic activity was explored centrally and peripherally using hot plate and writhing tests, respectively. In addition, anti-ulcerogenic activity was assayed in colon and gastric tissues. Results: Foliar extracts of A. fragrantissima exhibited anti-inflammatory, central and peripheral analgesic activities. Moreover, both non-polar and polar fractions revealed protective effects against rat ulcerative colitis and gastric ulcers. Conclusion: A. fragrantissima extracts possess anti-inflammatory, central and peripheral analgesic activities in addition to protective properties in colonic and gastric tissues.

Description

© 2015 South African Association of Botanists. cc-by

Keywords

Achillea fragrantissima, Analgesic, Anti-inflammatory, Anti-ulcerogenic, Egyptian folk medicine

Citation

Abdel-Rahman, R.F., Alqasoumi, S.I., El-Desoky, A.H., Soliman, G.A., Pare, P.W., & Hegazy, M.-E.F.. 2015. Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.). South African Journal of Botany, 98. https://doi.org/10.1016/j.sajb.2015.02.009

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