Synthetic studies on a model system for the spirobicyclic ring system of oscillatoxin D

Date

1997-05

Journal Title

Journal ISSN

Volume Title

Publisher

Texas Tech University

Abstract

This thesis describes the development of some synthetic methodology applicable to the preparation of the spirobicyclic ring system of the marine natural product oscillatoxin D (1, Figure 1.1). Our goal was to find an efficient way to synthesize a major intermediate for the model compound (2) and thus to provide a guide for the subsequent synthesis of the natural product. Oscillatoxin D has shown some antileukemic activity and it might have undiscovered biological activity. It is a possible drug candidate.

Description

Keywords

Marine toxins, Natural products, Oscillatoriaceae, Cyanobacterial toxins

Citation