Bioactive hydroperoxyl cembranoids from the Red Sea soft coral Sarcophyton glaucum

Abstract

A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites. © 2012 by the authors; licensee MDPI.

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Keywords

Cancer chemo-preventive activity, Diterpenes, Sarcophyton glaucum, Soft coral

Citation

Hegazy, M.-E.F., Gamal, Eldeen, A.M., Shahat, A.A., Abdel-Latif, F.F., Mohamed, T.A., Whittlesey, B.R., & Pare, P.W.. 2012. Bioactive hydroperoxyl cembranoids from the Red Sea soft coral Sarcophyton glaucum. Marine Drugs, 10(1). https://doi.org/10.3390/md10010209

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