Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells

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martinez-zaguilan_article.pdf (1.23 MB)

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2015

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Abstract

Background: Ahe V-ATPase has been proposed to function at the plasma membrane in tumor cell invasion. Results: Inhibition of plasma membrane V-ATPases prevented invasion of MDA-MB-231 cells. Conclusion: Activity of plasma membrane V-ATPases is critical for breast cancer cell invasion. Significance: Plasma membrane V-ATPases are a possible therapeutic target to limit metastasis.

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. cc-by

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Cotter, K., Capecci, J., Sennoune, S., Huss, M., Maier, M., Martinez-Zaguilan, R., & Forgac, M.. 2015. Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells. Journal of Biological Chemistry, 290(6). https://doi.org/10.1074/jbc.M114.611210

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https://doi.org/10.1074/jbc.M114.611210
 https://hdl.handle.net/2346/93773

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