Carotane sesquiterpenes fromFerula vesceritensis:in silicoanalysis as SARS-CoV-2 binding inhibitors

Abstract

Two sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as, ten known analogues (3-10), and two sesquiterpene coumarins (11-12) were isolated from an organic root extract ofFerula vesceritensis(Fam. Apiaceae). Chemical structures were elucidated based on IR, 1D- and 2D-NMR and HRMS, spectroscopic analyses. With molecular overlap observed between two protease inhibitors that are being examined as anti-COVID-19 drugs, and sesquiterpenes isolated here, metabolite molecular docking calculations were made using the main protease (Mpro), which is required for viral multiplication as well as RNA-dependent RNA polymerase (RdRp).In silicobinding-inhibition analysis predicted that selectF. vesceritensissesquiterpenes can bind to these enzymes required for viral replication. Structures of the isolated constituents were also consistent with the chemo-systematic grouping ofF. vesceritensissecondary metabolites with otherFerulaspecies.

Description

© The Royal Society of Chemistry 2020. cc-by-nc

Keywords

Citation

Mohamed, T.A., Elshamy, A.I., Ibrahim, M.A.A., Zellagui, A., Moustafa, M.F., Abdelrahman, A.H.M., Ohta, S., Pare, P.W., & Hegazy, M.-E.. 2020. Carotane sesquiterpenes fromFerula vesceritensis:in silicoanalysis as SARS-CoV-2 binding inhibitors. RSC Advances, 10(57). https://doi.org/10.1039/d0ra06901a

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