Improving vitamin D status in bariatric surgery subjects with monthly high-dose ergocalciferol: A randomized clinical trial

Date

2022

Authors

Galyean, Shannon (TTU)
Syn, David
Subih, Hadil S.
Boylan, Mallory (TTU)

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Abstract

Background: Vitamin D insufficiency is common before and after bariatric surgery. Optimal supplementation to treat vitamin D insufficiency is not clearly defined. Objective: Determine if serum 25 (OH) D levels improve by the consumption of an additional monthly ergocalciferol supplement by subjects after bariatric surgery. Study design: Thirty-two subjects were randomly divided to receive an additional 100,000 IUs of ergocalciferol monthly after bariatric surgery (n=10) or standard level vitamin D supplement after bariatric surgery (n=22). Serum 25 (OH) D, calcium, and hemoglobin A1c levels were measured preoperatively and one year after bariatric surgery. Results: Mean changes in BMI at 1-year post-operation was -18.12±6.46 kg/m2in the control group versus -18.84±4.7 kg/m2; p=0.638 in the vitamin D group. One year after bariatric surgery, the mean changes from baseline in vitamin D levels were 2.69±9.4 and 12.4±17.0 ng/mL in control and intervention groups, respectively. The treated group showed a marginally higher mean increase in Vitamin D than the control group, p=0.059. Other mean changes at 1-year post-surgery that were not significantly different include calcium -0.264±0.45 and -0.21±0.509 mg/dl in control and intervention groups, respectively and HbA1c -1.0±1.21 and -0.95±0.071% in control and intervention groups, respectively. Conclusion: This study showed 100,000 IUs ergocalciferol once a month is a safe and effective treatment for vitamin D insufficiency in most patients having bariatric surgery.

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© 2022 Hogrefe Verlag GmbH & Co. KG. All rights reserved. cc-by-nc-nd

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Keywords

Bariatric surgery, deficiency, Ergocalciferol, supplement, vitamin D

Citation

Galyean, S., Syn, D., Subih, H.S., & Boylan, M.. 2022. Improving vitamin D status in bariatric surgery subjects with monthly high-dose ergocalciferol: A randomized clinical trial. International Journal for Vitamin and Nutrition Research, 92(2). https://doi.org/10.1024/0300-9831/a000728

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