Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review

dc.creatorLevitt, Danielle E. (TTU)
dc.creatorLuk, Hui Ying (TTU)
dc.creatorVingren, Jakob L.
dc.date.accessioned2023-04-20T18:37:07Z
dc.date.available2023-04-20T18:37:07Z
dc.date.issued2023
dc.description© 2022 by the authors. cc-by
dc.description.abstractSkeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and degradation. Several intracellular signaling pathways control this balance, including mammalian/mechanistic target of rapamycin (mTOR) complex 1 (C1). Activation of this pathway in skeletal muscle is controlled, in part, by nutrition (e.g., amino acids and alcohol) and exercise (e.g., resistance exercise (RE)). Acute and chronic alcohol use can result in myopathy, and evidence points to altered mTORC1 signaling as a contributing factor. Moreover, individuals who regularly perform RE or vigorous aerobic exercise are more likely to use alcohol frequently and in larger quantities. Therefore, alcohol may antagonize beneficial exercise-induced increases in mTORC1 pathway signaling. The purpose of this review is to synthesize up-to-date evidence regarding mTORC1 pathway signaling and the independent and combined effects of acute alcohol and RE on activation of the mTORC1 pathway. Overall, acute alcohol impairs and RE activates mTORC1 pathway signaling; however, effects vary by model, sex, feeding, training status, quantity, etc., such that anabolic stimuli may partially rescue the alcohol-mediated pathway inhibition. Likewise, the impact of alcohol on RE-induced mTORC1 pathway signaling appears dependent on several factors including nutrition and sex, although many questions remain unanswered. Accordingly, we identify gaps in the literature that remain to be elucidated to fully understand the independent and combined impacts of alcohol and RE on mTORC1 pathway signaling.
dc.identifier.citationLevitt, D.E., Luk, H.-Y., & Vingren, J.L.. 2023. Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review. Biomolecules, 13(1). https://doi.org/10.3390/biom13010002
dc.identifier.urihttps://doi.org/10.3390/biom13010002
dc.identifier.urihttps://hdl.handle.net/2346/92983
dc.language.isoeng
dc.subjectalcohol
dc.subjectmTOR
dc.subjectmyopathy
dc.subjectprotein synthesis
dc.subjectresistance exercise
dc.titleAlcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review
dc.typeReview

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