Bistability in a model of tumor-immune system interactions with an oncolytic viral therapy

dc.creatorVithanage, G. V.R.K. (TTU)
dc.creatorWei, Hsiu Chuan
dc.creatorJang, Sophia R.J. (TTU)
dc.date.accessioned2023-04-11T16:43:08Z
dc.date.available2023-04-11T16:43:08Z
dc.date.issued2022
dc.description© 2022 the Author(s), licensee AIMS Press. cc-by
dc.description.abstractA mathematical model of tumor-immune system interactions with an oncolytic virus therapy for which the immune system plays a twofold role against cancer cells is derived. The immune cells can kill cancer cells but can also eliminate viruses from the therapy. In addition, immune cells can either be stimulated to proliferate or be impaired to reduce their growth by tumor cells. It is shown that if the tumor killing rate by immune cells is above a critical value, the tumor can be eradicated for all sizes, where the critical killing rate depends on whether the immune system is immunosuppressive or proliferative. For a reduced tumor killing rate with an immunosuppressive immune system, that bistability exists in a large parameter space follows from our numerical bifurcation study. Depending on the tumor size, the tumor can either be eradicated or be reduced to a size less than its carrying capacity. However, reducing the viral killing rate by immune cells always increases the effectiveness of the viral therapy. This reduction may be achieved by manipulating certain genes of viruses via genetic engineering or by chemical modification of viral coat proteins to avoid detection by the immune cells.
dc.identifier.citationVithanage, G.V.R.K., Wei, H.-C., & Jang, S.R.-J.. 2022. Bistability in a model of tumor-immune system interactions with an oncolytic viral therapy. Mathematical Biosciences and Engineering, 19(2). https://doi.org/10.3934/mbe.2022072
dc.identifier.urihttps://doi.org/10.3934/mbe.2022072
dc.identifier.urihttps://hdl.handle.net/2346/92703
dc.language.isoeng
dc.subjectGlobal sensitivity analysis
dc.subjectImmune impairment
dc.subjectImmune system
dc.subjectNumerical bifurcation analysis
dc.subjectOncolytic virus therapy
dc.subjectTumor
dc.titleBistability in a model of tumor-immune system interactions with an oncolytic viral therapy
dc.typeArticle

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