RADIO-adaptive response to environmental exposures at chernobyl

dc.creatorRodgers, Brenda E. (TTU)
dc.creatorHolmes, Kristen M.
dc.date.accessioned2023-09-14T18:23:45Z
dc.date.available2023-09-14T18:23:45Z
dc.date.issued2008
dc.descriptioncc-by-nc
dc.description.abstractThe genetic consequences resulting from environmental exposure to ionizing radiation have a significant impact on both radiation regulatory policies and the comprehension of the human health risks associated with radiation exposure. The primary objectives of the study were to assess 1) genotoxicity of exposure to radiation as a function of absorbed dose and dose rate, and 2) induction of a radio-adaptive response following a priming dose at varying dose rates. Results demonstrated that sub-acute environmental exposures of 10cGy gamma radiation resulted in indistinguishable levels of chromosomal damage as compared to controls. A radio-adaptive response was observed in all experimental groups, exposed to a subsequent acute challenge dose of 1.5 Gy, demonstrating that low dose rates of low energy transfer (LET) radiation are effective in reducing genetic damage from a subsequent acute low-LET radiation exposure. Furthermore, the data presented herein demonstrate a potential beneficial effect of sub-chronic exposure to low levels of low-LET radiation in an environmental setting and do not support the Linear No Threshold (LNT) hypothesis. 10.2203. © 2008 University of Massachusetts.
dc.identifier.citationRodgers, B.E., & Holmes, K.M.. 2008. RADIO-adaptive response to environmental exposures at chernobyl. Dose-Response, 6(2). https://doi.org/10.2203/dose-response.07-008.Rodgers
dc.identifier.urihttps://doi.org/10.2203/dose-response.07-008.Rodgers
dc.identifier.urihttps://hdl.handle.net/2346/96140
dc.language.isoeng
dc.subjectBALB/c
dc.subjectChernobyl
dc.subjectHormesis
dc.subjectIonizing radiation
dc.subjectMN assay
dc.subjectRadio-adaptive response
dc.titleRADIO-adaptive response to environmental exposures at chernobyl
dc.typeArticle

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