BioNutrients-2: Improvements to the BioNutrients-1 Nutrient Production System

dc.creatorBall, Natalie
dc.creatorKagawa, Hiromi
dc.creatorHindupur, Aditya
dc.creatorKostakis, Aphrodite
dc.creatorHogan, John
dc.creatorVillanueva, Alyssa
dc.creatorSharif, Sean
dc.creatorDonovan, Frances
dc.creatorSettles, Mark
dc.creatorSims, Kevin
dc.creatorGresser, Amy
dc.date.accessioned2021-06-24T20:15:34Z
dc.date.available2021-06-24T20:15:34Z
dc.date.issued7/12/2021
dc.descriptionNatalie Ball, KBR
dc.descriptionHiromi Kagawa, SETI Institute
dc.descriptionAditya Hindupur KBR
dc.descriptionAphrodite Kostakis, KBR
dc.descriptionJohn Hogan, NASA
dc.descriptionAlyssa Villanueva, Logyx LLC
dc.descriptionSean Sharif, Logyx LLC
dc.descriptionFrances Donovan, NASA Ames
dc.descriptionMark Settles, NASA Ames
dc.descriptionKevin Sims, KBR
dc.descriptionAmy Gresser, KBR
dc.descriptionICES204: Bioregenerative Life Supporten
dc.descriptionThe 50th International Conference on Environmental Systems was held virtually on 12 July 2021 through 14 July 2021.en_US
dc.description.abstractThe BioNutrients (BN) project aims to develop an on-demand biological production system capable of rapid and safe delivery of multiple nutrients in single-use production packs for long-duration missions. The general concept of this system is to develop edible engineered microorganisms that produce nutrients for human consumption following long-term storage, revival, and growth. BN-1 is a five-year flight project currently on the International Space Station (ISS). It is testing the long-term storage of various microorganisms for the biomanufacturing of space-relevant compounds and validating the performance of the first generation of production packs. The BN-2 project expands the BN-1 flight project scope by introducing novel products, broadening the range of microbial food sources, and improving upon production pack hardware. We are optimizing the biomanufacturing platform for in situ production of yogurt and kefir on the ISS. BN-2 also will test engineered microorganisms, including a probiotic strain, to produce carotenoids or follistatin. To improve the feasibility of this technology for mission use, we transitioned from a hard-shell pack to a second-generation fluorinated ethylene propylene (FEP) bag. The single-use FEP bioreactor facilitates growth of target organisms in a contaminant free environment, while reducing mass and volume compared to the BN-1 hardware. These bioreactors will be employed for production of additional space-relevant products in the BN-2 project. On-orbit testing of FEP production packs will enable optimization of the platform for eventual flight use by the crew.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.otherICES-2021-331
dc.identifier.urihttps://hdl.handle.net/2346/87260
dc.language.isoengen_US
dc.publisher50th International Conference on Environmental Systemsen_US
dc.subjectBioNutrients
dc.subjectyogurt
dc.subjectprobiotic
dc.subjectkefir
dc.subjectbiomanufacturing
dc.subjectnutrient production
dc.titleBioNutrients-2: Improvements to the BioNutrients-1 Nutrient Production Systemen_US
dc.typePresentationen_US

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