GAP chemistry & its applications

Asymmetric synthesis and catalysis are important tools in chemistry, pharmaceutical and material sciences. Increasingly large numbers of drugs and building blocks of materials show chirality in their structures. Group-assisted-purification (GAP) technology plays an important role in both general organic synthesis and asymmetric chemistry. It involves new achiral and chiral reagents and introduces alternative method of purification and recrystallization. A large amount of organic solvents and silica gels can be avoided by using GAP technology resulting in environmentally friendly work-up. Till now, our group identified different applications of GAP chemistry in asymmetric synthesis and catalysis including the new form of chirality, known as Multi-layer 3D chirality. Sandwich typed organic molecule with multi-layer 3D chirality shows fluorescent and luminescent properties, which could open a new research area in chemical, medicinal, and material science in the future. It could also be a new catalyst besides BINOL/BINAP and others in asymmetric synthesis and catalysis. This thesis has invoved building block molecules to synthesize multi-layer 3D chiral organic compounds and one pot synthesis of N-phosphonyl amide. Besides that, it also demonstrated the synthesis of α-aminomethyl enaminones and α- bromo nitroalkane using GAP chemistry.