Not so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortex

dc.creatorSchlund, Michael W.
dc.creatorBrewer, Adam T.
dc.creatorRichman, David M. (TTU)
dc.creatorMagee, Sandy K.
dc.creatorDymond, Simon
dc.date.accessioned2023-02-22T15:23:55Z
dc.date.available2023-02-22T15:23:55Z
dc.date.issued2015
dc.description© 2015 Schlund, Brewer, Richman, Magee and Dymond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.description.abstractThe dorsal anterior cingulate (adACC) and dorsal medial prefrontal cortex (dmPFC) play a central role in the discrimination and appraisal of threatening stimuli. Yet, little is known about what specific features of threatening situations recruit these regions and how avoidance may modulate appraisal and activation through prevention of aversive events. In this investigation, 30 healthy adults underwent functional neuroimaging while completing an avoidance task in which responses to an Avoidable CS+ threat prevented delivery of an aversive stimulus, but not to an Unavoidable CS+ threat. Extinction testing was also completed where CSs were presented without aversive stimulus delivery and an opportunity to avoid. The Avoidable CS+ relative to the Unavoidable CS+ was associated with reductions in ratings of negative valence, fear, and US expectancy and activation. Greater regional activation was consistently observed to the Unavoidable CS+ during avoidance, which declined during extinction. Individuals exhibiting greater aversive discounting—that is, those more avoidant of immediate monetary loss compared to a larger delayed loss—also displayed greater activation to the Unavoidable CS+, highlighting aversive discounting as a significant individual difference variable. These are the first results linking adACC/dmPFC reactivity to avoidance-based reductions of aversive events and modulation of activation by individual differences in aversive discounting.en_US
dc.identifier.citationSchlund MW, Brewer AT, Richman DM, Magee SK and Dymond S (2015) Not so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortex. Front. Behav. Neurosci. 9:142. doi: 10.3389/fnbeh.2015.00142en_US
dc.identifier.urihttps://doi.org/10.3389/fnbeh.2015.00142
dc.identifier.urihttps://hdl.handle.net/2346/90802
dc.language.isoengen_US
dc.subjectAvoidanceen_US
dc.subjectThreatsen_US
dc.subjectFearen_US
dc.subjectAnterior Cingulateen_US
dc.subjectMedial Prefrontal Cortex (mPFC)en_US
dc.subjectLoss Discountingen_US
dc.subjectAnxietyen_US
dc.subjectNeuroimagingen_US
dc.titleNot so bad: avoidance and aversive discounting modulate threat appraisal in anterior cingulate and medial prefrontal cortexen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
richman_article.pdf
Size:
6.31 MB
Format:
Adobe Portable Document Format
Description:
Main article with TTU Libraries cover page

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections