Euphosantianane A–D: Antiproliferative premyrsinane diterpenoids from the endemic Egyptian plant euphorbia sanctae-catharinae

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dc.creatorHegazy, Mohamed Elamir F.
dc.creatorHamed, Ahmed R.
dc.creatorIbrahim, Mahmoud A.A.
dc.creatorTalat, Zienab
dc.creatorReda, Eman H.
dc.creatorAbdel-Azim, Nahla S.
dc.creatorHammouda, Faiza M.
dc.creatorNakamura, Seikou
dc.creatorMatsuda, Hisashi
dc.creatorHaggag, Eman G.
dc.creatorParé, Paul W. (TTU)
dc.creatorEfferth, Thomas
dc.date.accessioned2023-03-31T15:59:49Z
dc.date.available2023-03-31T15:59:49Z
dc.date.issued2018
dc.description© 2018 by the authors. cc-by
dc.description.abstractEuphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.
dc.identifier.citationHegazy, M.-E.F., Hamed, A.R., Ibrahim, M.A.A., Talat, Z., Reda, E.H., Abdel-Azim, N.S., Hammouda, F.M., Nakamura, S., Matsuda, H., Haggag, E.G., Pare, P.W., & Efferth, T.. 2018. Euphosantianane A–D: Antiproliferative premyrsinane diterpenoids from the endemic Egyptian plant euphorbia sanctae-catharinae. Molecules, 23(9). https://doi.org/10.3390/molecules23092221
dc.identifier.urihttps://doi.org/10.3390/molecules23092221
dc.identifier.urihttps://hdl.handle.net/2346/92278
dc.language.isoeng
dc.subjectDiterpenes
dc.subjectEuphorbia sanctae-catharinae
dc.subjectEuphorbiaceae
dc.subjectFlavonoids
dc.subjectTDDTF-ECD
dc.subjectTumor anti-proliferative activity
dc.titleEuphosantianane A–D: Antiproliferative premyrsinane diterpenoids from the endemic Egyptian plant euphorbia sanctae-catharinae
dc.typeArticle

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