Haem toxicity provides a competitive advantage to the clinically relevant Staphylococcus aureus small colony variant phenotype

dc.creatorHerrin, Brittany E.
dc.creatorIslam, Shariful
dc.creatorRentschler, Kaitlin N.
dc.creatorPert, Lauren H.
dc.creatorKopanski, Stephanie P.
dc.creatorWakeman, Catherine A.
dc.date.accessioned2021-09-29T19:53:30Z
dc.date.available2021-09-29T19:53:30Z
dc.date.issued2021
dc.description© 2021 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.description.abstractMicroorganisms encounter toxicities inside the host. Many pathogens exist as subpopulations to maximize survivability. Subpopulations of Staphylococcus aureus include antibiotic-tolerant small colony variants (SCVs). These mutants often emerge following antibiotic treatment but can be present in infections prior to antibiotic exposure. We hypothesize that haem toxicity in the host selects for respiration-deficient S. aureus SCVs in the absence of antibiotics. We demonstrate that some but not all respiration-deficient SCV phenotypes are more protective than the haem detoxification system against transient haem exposure, indicating that haem toxicity in the host may contribute to the dominance of menaquinone-deficient and haem-deficient SCVs prior to antibiotic treatment.en_US
dc.identifier.citationHerrin, B. E., Islam, S., Rentschler, K. N., Pert, L. H., Kopanski, S. P., & Wakeman, C. A. (2021). Haem toxicity provides a competitive advantage to the clinically relevant staphylococcus aureus small colony variant phenotype. Microbiology, 167(4). https://doi.org/10.1099/mic.0.001044en_US
dc.identifier.urihttps://doi.org/10.1099/mic.0.001044
dc.identifier.urihttps://hdl.handle.net/2346/87968
dc.language.isoengen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectSCVen_US
dc.subjectAntibiotic Toleranceen_US
dc.subjectHaem Toxicityen_US
dc.subjectRespirationen_US
dc.subjectSmall Colony Variantsen_US
dc.titleHaem toxicity provides a competitive advantage to the clinically relevant Staphylococcus aureus small colony variant phenotypeen_US
dc.typeArticleen_US

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