Reversible interconversion of pharmaceutical salt polymorphs facilitated by mechanical methods

dc.creatorMa, Liulei (TTU)
dc.creatorZheng, Qixuan (TTU)
dc.creatorUnruh, Daniel K. (TTU)
dc.creatorHutchins, Kristin M. (TTU)
dc.date.accessioned2023-07-27T17:31:18Z
dc.date.available2023-07-27T17:31:18Z
dc.date.issued2023
dc.descriptionThis journal is © The Royal Society of Chemistry 2023en_US
dc.description.abstractSalification of the drug trimethoprim with enantiopure D- or L-lactic acid afforded salts with up to five times improved solubility. Both salts are polymorphic and we demonstrate fully reversible interconversion (cycling) between the drug polymorphs using mechanochemistry and slurry methods. We show drug polymorph interconversion requires both solvent contact and mechanical force, revealing strategies for cycling between solid material forms.en_US
dc.identifier.citationMa, L., Zheng, Q., Unruh, D. K., & Hutchins, K. M. (2023). Reversible interconversion of pharmaceutical salt polymorphs facilitated by mechanical methods. Chemical Communications, 59(50), 7779–7782. https://doi.org/10.1039/d3cc02188ben_US
dc.identifier.urihttps://doi.org/10.1039/d3cc02188b
dc.identifier.urihttps://hdl.handle.net/2346/95288
dc.language.isoengen_US
dc.subjectPharmaceutical Saltsen_US
dc.subjectTrimethoprimen_US
dc.subjectSolubility Improvementen_US
dc.subjectMechanochemistryen_US
dc.subjectSlurry Methodsen_US
dc.titleReversible interconversion of pharmaceutical salt polymorphs facilitated by mechanical methodsen_US
dc.typeArticleen_US

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