Vascular remodeling is associated with increased permeability of experimental brain metastases of breast cancer

dc.contributor.committeeChairLockman, Paul
dc.contributor.committeeMemberGunaje, Jayarama
dc.contributor.committeeMemberRao, U. S.
dc.contributor.committeeMemberSmith, Quentin
dc.contributor.committeeMemberWang, Ming-Hai
dc.creatorBohn, Kaci Annette
dc.date.accessioned2020-02-25T15:45:12Z
dc.date.available2020-02-25T15:45:12Z
dc.date.issued2011-08
dc.description.abstract[From Chapter 1] In summary, this dissertation is a quantitative evaluation of the vascularity and/or angiogenesis involved in the altered permeability of brain metastases of breast cancer. The data suggest that multiple mechanisms play a role in altering the integrity of the BTB. Our data also illuminate the role of bevacizumab in the decreased efficacy of chemotherapeutics during combinatorial therapy in experimental brain metastases of breast cancer. Lastly, our data point to an exciting novel combination therapy that may significantly decrease the formation of brain metastases of breast cancer.en_US
dc.identifier.urihttps://hdl.handle.net/2346/85660
dc.language.isoeng
dc.rights.availabilityUnrestricted.
dc.subjectVEGF/Angiopoietin-2 pathway
dc.subjectBrain metastases
dc.subjectBrain metastases of breast cancer
dc.subjectBreast cancer
dc.subjectMetastatic burden
dc.titleVascular remodeling is associated with increased permeability of experimental brain metastases of breast canceren_US
dc.typeDissertation
thesis.degree.departmentTTUHSC - Pharmaceutical Sciences
thesis.degree.disciplineTTUHSC - Biomedical Sciences
thesis.degree.grantorTexas Tech University Health Sciences Center
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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