2023-09-132023-09-132014Xiong, Y., Mei, H., Wu, L., Han, J., Pan, Y., & Li, G.. 2014. Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction. Beilstein Journal of Organic Chemistry, 10. https://doi.org/10.3762/bjoc.10.57https://doi.org/10.3762/bjoc.10.57https://hdl.handle.net/2346/96039cc-byA variety of chiral N-phosphinyl a-imino esters have been synthesized for the first time from ketoesters and phosphinylamide, which were then reduced by L-selectride to give the corresponding N-phosphinyl-protected a-amino esters. The reduction proceeded very well with excellent chemical yields (88-98%) as well as high diastereoselectivities (96:4 to 99:1). Some of these products could be obtained without column chromatography and recrystallization. The chiral phosphinyl auxiliary could be easily cleaved under acidic conditions. © 2014 Xiong et al; licensee Beilstein-Institut.engGroup-assisted purificationPhosphinyl auxiliaryReductionα-amino esterα-imino esterArticle