2023-05-112023-05-112021Dunning, T.J., Unruh, D.K., Bosch, E., & Groeneman, R.H.. 2021. Controlling topology within halogen-bonded networks by varying the regiochemistry of the cyclobutane-based nodes. Molecules, 26(11). https://doi.org/10.3390/molecules26113152https://doi.org/10.3390/molecules26113152https://hdl.handle.net/2346/93458© 2021 by the authors. Licensee MDPI, Basel, Switzerland. cc-byThe formation of a pair of extended networks sustained by halogen bonds based upon two regioisomers of a photoproduct, namely rctt-1,3-bis(4-pyridyl)-2,4-bis(phenyl)cyclobutane (ht-PP) and rctt-1,2-bis(4-pyridyl)-3,4-bis(phenyl)cyclobutane (hh-PP), that have varied topology is reported. These networks are held together via I· · · N halogen bonds between the photoproduct and the halogen-bond donor 1,4-diiodoperchlorobenzene (C6 I2 Cl4). The observed topology in each solid is controlled by the regiochemical position of the halogen-bond accepting 4-pyridyl group. This paper demonstrates the ability to vary the topology of molecular networks by altering the position of the halogen bond acceptor within the cyclobutane-based node.engCrystal engineeringHalogen bondingOrganic solid stateTopologyArticle