2023-09-112023-09-112023Zhang, S., Chen, D., Wang, J.-Y., Yan, S., & Li, G.. 2023. Four-layer folding framework: design, GAP synthesis, and aggregation-induced emission. Frontiers in Chemistry, 11. https://doi.org/10.3389/fchem.2023.1259609https://doi.org/10.3389/fchem.2023.1259609https://hdl.handle.net/2346/96005Copyright © 2023 Zhang, Chen, Wang, Yan and Li. cc-byThe design and synthesis of a type of [1 + 4 + 2] four-layer framework have been conducted by taking advantage of Suzuki–Miyaura cross-coupling and group-assisted purification (GAP) chemistry. The optimized coupling of double-layer diboronic esters with 1-bromo-naphth-2-yl phosphine oxides resulted in a series of multilayer folding targets, showing a broad scope of substrates and moderate to excellent yields. The final products were purified using group-assisted purification chemistry/technology, achieved simply by washing crude products with 95% EtOH without the use of chromatography and recrystallization. The structures were fully characterized and assigned by performing X-ray crystallographic analysis. UV–vis absorption, photoluminescence (PL), and aggregation-induced emission (AIE) were studied for the resulting multilayer folding products.engAIEGAP chemistrymultilayer folding moleculesphosphine oxidesSuzuki–Miyaura couplingArticle