2024-03-182024-03-182024Chen, D., Bao, Y., Yan, S., Wang, J., Zhang, Y., & Li, G.. 2024. Photocatalytic Multicomponent Annulation of Amide-Anchored 1,7-Diynes Enabled by Deconstruction of Bromotrichloromethane. Molecules, 29(4). https://doi.org/10.3390/molecules29040782https://doi.org/10.3390/molecules29040782https://hdl.handle.net/2346/97737© 2024 by the authors. cc-byWe present the first example of visible-light-mediated multicomponent annulation of 1,7-diynes by taking advantage of quadruple cleavage olf carbon-halogen bonds of BrCCl3 to generate a C1 synthon, which was adeptly applied to the preparation of skeletally diverse 3-benzoyl-quinolin-2(1H)-one acetates in moderate to good yields. Controlled experiments demonstrated that H2O acted as both oxygen and hydrogen sources, and gem-dichlorovinyl carbonyl compound exhibited as a critical intermediate in this process. The mechanistic pathway involves Kharasch-type addition/6-exo-dig cyclization/1,5-(SN”)-substitution/elimination/binucleophilic 1,6-addition/proton transfer/tautomerization sequence.eng1,7-diynesC1 chemistryKharasch-type additionmulticomponent annulationphotocatalyticArticle