2023-08-162023-08-162023Kennedy, P., Ratnaparkhi, R., Lee, J., Glenn, J.E., Kelly, P.J., Kimminau, K.S., Assimonye, S., & Ramaswamy, M.. 2023. Case example of a jail-based cancer prevention clinical trial: social determinants of health framework, novel experimental design, and retention strategies to facilitate long-term follow-up of clinical trial participants. Journal of Clinical and Translational Science. https://doi.org/10.1017/cts.2023.561https://doi.org/10.1017/cts.2023.561https://hdl.handle.net/2346/95636© 2023 Cambridge University Press. All rights reserved. cc-by-nc-ndClinical trials conducted with incarcerated populations are rare. We present a case example of one such jail-based cancer prevention clinical trial to demonstrate the importance of including a theory-driven approach to intervention framing, novel experimental designs to boost access to low-risk trials, and retention strategies for long- term follow-up of hard-to-reach populations. As such we offer a social determinants of health framework to ensure cancer prevention research is conducted through the lenses of health promotion and health equity. Deviations from the gold-standard randomized control design, transparent systematic allotment, and street-based outreach retention strategies contribute to the feasibility of conducting clinical trials in carceral settings and after people leave jail. Best practices presented can be used in design and conduct of future clinical trials with criminal legal system involved populations.engcancer preventionclinical trialjailsocial determinants of healthArticle