2023-06-162023-06-162023Elsaid, M., Ge, R., Liu, C., Maiti, D., Ge, H., Angew. Chem. Int. Ed. 2023, 62, e202303110. https://doi.org/10.1002/anie.202303110https://doi.org/10.1002/anie.202303110https://hdl.handle.net/2346/94641This is the peer reviewed version of the article, which has been published in final form at https://doi.org/10.1002/anie.202303110. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Carbazole alkaloids hold great potential in pharmaceutical and material sciences. However, the current approaches for C1 functionalization of carbazoles rely on the use of a pre-installed directing group, severely limiting their applicability and hindering their overall efficiency. Herein, we report for the first time the development of direct Pd-catalyzed C−H alkylation and acylation of carbazoles assisted by norbornene (NBE) as a transient directing mediator. Notably, the involvement of a six-membered palladacycle intermediate was suggested in this case, representing the first example of such intermediacy within the extensively studied Pd/norbornene reactions realm.engC(sp2)-H FunctionalizationCarbazoleNorbornenePalladiumTransient Directing MediatorArticle