Browsing by Author "Sooriyaarachchi, Dilshan C."
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Item Comparative Study of Photonic Crystals Imaging Using Fourier Tychographic Microscopy and Dual Space Microscopy(2017-12) Sooriyaarachchi, Dilshan C.We will study imaging periodic photonic crystals using Fourier Phytocographic Microscopy (FPM) and Dual Space Microscopy (DSM) using a Hemispherical Digital Condenser (HDC). We intend to show that both techniques have the capability to image photonic crystals below Rayleigh resolution limit. Simulations of both phase recovery techniques proved that we can images photonic crystals with a period upto ~(𝑁𝐴𝑜+𝑁𝐴𝑐) which is below the classical limit. Here 𝜆 is the wavelength of light, 𝑁𝐴𝑜 is the numerical aperture of the objective lens and 𝑁𝐴𝑐 is the numerical aperture of the condenser. However, it was found that experimentally FPM fails to recover periodic structures below Rayleigh resolution limit whereas DSM still succeeds. Failure in FPM can be attributed unwanted reflections in the HDC.Item Development of Hybrid Microfabrication Techniques for Biomedical Applications(2020-08) Sooriyaarachchi, Dilshan C.; Tan, George Z.; Du, Dongping; Xu, Changxue; Li, WeiLatest tissue engineering strategies for musculoskeletal tissues regeneration focus on creating a biomimetic microenvironment closely resembling the natural topology of extracellular matrix. Proceeding work presents a novel meniscus tissue scaffold fabricated by a hybrid additive manufacturing technology to closely resemble the natural topology of extracellular matrix. A skeletal scaffold was 3D printed and a layer of random or aligned polycaprolactone and collagen nanofibers were embedded between two frames. A compression test was performed to study the mechanical properties of the system. Human osteosarcoma cells were cultured in the scaffold for 7 days to evaluate the effect of scaffold microstructure on cell growth. With reinforced nanofibers, the hybrid scaffold showed superior compression strength compared to 3D printed scaffold without nanofibers. The hybrid scaffold induced the cells to organize into an aligned structure. The study shows the potential of hybrid bio fabrication process to be developed as a scalable platform for biomimetic scaffolds with patterned fibrous microstructure. It will facilitate future development of clinical solutions for musculoskeletal tissue regeneration. Integration of nanomaterials in microfluidic devices has emerged as a new research paradigm. Microfluidic devices composed of ZnO nanowires have been developed for the collection of urine extracellular vesicles (EVs) at high efficiency and in situ extraction of various microRNAs (miRNAs). The devices can be used for diagnosing various disease including kidney diseases and cancers. One of the research needs for developing micro-total-analysis systems is to enhance extraction efficiency. This paper presents a novel fabrication method for a herringbone patterned microfluidic device anchored with ZnO nanowire arrays. The substrates with herringbone patterns were created by maskless photolithography. The ZnO nanowire arrays were grown on the substrates by chemical bathing. The patterned design was to introduce spiral circulation as opposed to laminar flow in traditional devices to increase the mixing and contact of the urine sample with ZnO nanowires.