Browsing by Author "Yang, Yang"
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Item Fabrication of Silicon-based Planar Structural Charged Particle Detector(2014-05-15) Yang, Yang; Gale, Richard O.; Li, ChangzhiCharged particle detectors are widely used in nuclear physics, astrophysics and environmental monitoring areas. The applications include charged particle spectroscopy, air monitoring, alpha beta counting, etc. This thesis outlines the basics of charged particle detection and spectroscopy. Then the design and fabrication concerns of the silicon-based planar structural detector are covered. After discussion of the process flow, a novel doping profile is proposed at last.Item Inter-stage performance and energy characteristics analysis of electric submersible pump based on entropy production theory(2024) Wang, Hui; Yang, Yang; Xi, Bin; Shi, Wei Dong; Wang, Chuan; Ji, Lei Lei; Song, Xiang Yu; He, Zhao Ming (TTU)The electric submersible pump (ESP) is a crucial apparatus utilized for lifting in the oil extraction process. Its lifting capacity is enhanced by the multi-stage tandem structure, but variations in energy characteristics and internal flow across stages are also introduced. In this study, the inter-stage variability of energy characteristics in ESP hydraulic systems is investigated through entropy production (EP) analysis, which incorporates numerical simulations and experimental validation. The EP theory facilitates the quantification of energy loss in each computational subdomain at all ESP stages, establishing a correlation between microscopic flow structure and energy dissipation within the system. Furthermore, the underlying causes of inter-stage variability in ESP hydraulic systems are examined, and the advantages and disadvantages of applying the EP theory in this context are evaluated. Consistent energy characteristics within the ESP, aligned with the distribution of internal flow structure, are provided by the EP theory, as demonstrated by our results. The EP theory also enables the quantitative analysis of internal flow losses and complements existing performance analysis methods to map the internal flow structure to hydraulic losses. Nonetheless, an inconsistency between the energy characterization based on EP theory and the traditional efficiency index when reflecting inter-stage differences is identified. This inconsistency arises from the exclusive focus of the EP theory on flow losses within the flow field, disregarding the quantification of external energy input to the flow field. This study provides a reference for the optimization of EP theory in rotating machinery while deeply investigating the energy dissipation characteristics of multistage hydraulic system, which has certain theoretical and practical significance.Item NIST interlaboratory study on glycosylation analysis of monoclonal antibodies: Comparison of results from diverse analytical methods(2020) De Leoz, Maria Lorna A.; Duewer, David L.; Fung, Adam; Liu, Lily; Yau, Hoi Kei; Potter, Oscar; Staples, Gregory O.; Furuki, Kenichiro; Frenkel, Ruth; Hu, Yunli; Sosic, Zoran; Zhang, Peiqing; Altmann, Friedrich; Grunwald-Grube, Clemens; Shao, Chun; Zaia, Joseph; Evers, Waltraud; Pengelley, Stuart; Suckau, Detlev; Wiechmann, Anja; Resemann, Anja; Jabs, Wolfgang; Beck, Alain; Froehlich, John W.; Huang, Chuncui; Li, Yan; Liu, Yaming; Sun, Shiwei; Wang, Yaojun; Seo, Youngsuk; An, Hyun Joo; Reichardt, Niels Christian; Ruiz, Juan Echevarria; Archer-Hartmann, Stephanie; Azadi, Parastoo; Bell, Len; Lakos, Zsuzsanna; An, Yanming; Cipollo, John F.; Pucic-Bakovic, Maja; Štambuk, Jerko; Lauc, Gordan; Li, Xu; Wang, Peng George; Bock, Andreas; Hennig, René; Rapp, Erdmann; Creskey, Marybeth; Cyr, Terry D.; Nakano, Miyako; Sugiyama, Taiki; Leung, Pui King Amy; Link-Lenczowski, Paweł; Jaworek, Jolanta; Yang, Shuang; Zhang, Hui; Kelly, Tim; Klapoetke, Song; Cao, Rui; Kim, Jin Young; Lee, Hyun Kyoung; Lee, Ju Yeon; Yoo, Jong Shin; Kim, Sa Rang; Suh, Soo Kyung; De Haan, Noortje; Falck, David; Lageveen-Kammeijer, Guinevere S.M.; Wuhrer, Manfred; Emery, Robert J.; Kozak, Radoslaw P.; Liew, Li Phing; Royle, Louise; Urbanowicz, Paulina A.; Packer, Nicolle H.; Song, Xiaomin; Everest-Dass, Arun; Lattová, Erika; Cajic, Samanta; Alagesan, Kathirvel; Kolarich, Daniel; Kasali, Toyin; Lindo, Viv; Chen, Yuetian; Goswami, Kudrat; Gau, Brian; Amunugama, Ravi; Jones, Richard; Stroop, Corné J.M.; Kato, Koichi; Yagi, Hirokazu; Kondo, Sachiko; Yuen, C. T.; Harazono, Akira; Shi, Xiaofeng; Magnelli, Paula E.; Kasper, Brian T.; Mahal, Lara; Harvey, David J.; O'Flaherty, Roisin; Rudd, Pauline M.; Saldova, Radka; Hecht, Elizabeth S.; Muddiman, David C.; Kang, Jichao; Bhoskar, Prachi; Menard, Daniele; Saati, Andrew; Merle, Christine; Mast, Steven; Tep, Sam; Truong, Jennie; Nishikaze, Takashi; Sekiya, Sadanori; Shafer, Aaron; Funaoka, Sohei; Toyoda, Masaaki; De Vreugd, Peter; Caron, Cassie; Pradhan, Pralima; Tan, Niclas Chiang; Mechref, Yehia (TTU); Patil, Sachin; Rohrer, Jeffrey S.; Chakrabarti, Ranjan; Dadke, Disha; Lahori, Mohammedazam; Zou, Chunxia; Cairo, Christopher; Reiz, Béla; Whittal, Randy M.; Lebrilla, Carlito B.; Wu, Lauren; Guttman, Andras; Szigeti, Marton; Kremkow, Benjamin G.; Lee, Kelvin H.; Sihlbom, Carina; Adamczyk, Barbara; Jin, Chunsheng; Karlsson, Niclas G.; Örnros, Jessica; Larson, Göran; Nilsson, Jonas; Meyer, Bernd; Wiegandt, Alena; Komatsu, Emy; Perreault, Helene; Bodnar, Edward D.; Said, Nassur; Francois, Yannis Nicolas; Leize-Wagner, Emmanuelle; Maier, Sandra; Zeck, Anne; Heck, Albert J.R.; Yang, Yang; Haselberg, Rob; Yu, Ying Qing; Alley, William; Leone, Joseph W.; Yuan, Hua; Stein, Stephen E.Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submit-ted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide communityderived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.Item Optimal Design of Slit Impeller for Low Specific Speed Centrifugal Pump Based on Orthogonal Test(2021) Yang, Yang; Zhou, Ling; Zhou, Hongtao; Lv, Wanning; Wang, Jian; Shi, Weidong; He, ZhaomingMarine centrifugal pumps are mostly used on board ship, for transferring liquid from one point to another. Based on the combination of orthogonal testing and numerical simulation, this paper optimizes the structure of a drainage trough for a typical low-specific speed centrifugal pump, determines the priority of the various geometric factors of the drainage trough on the pump performance, and obtains the optimal impeller drainage trough scheme. The influence of drainage tank structure on the internal flow of a low-specific speed centrifugal pump is also analyzed. First, based on the experimental validation of the initial model, it is determined that the numerical simulation method used in this paper is highly accurate in predicting the performance of low-specific speed centrifugal pumps. Secondly, based on the three factors and four levels of the impeller drainage trough in the orthogonal test, the orthogonal test plan is determined and the orthogonal test results are analyzed. This work found that slit diameter and slit width have a large impact on the performance of low-specific speed centrifugal pumps, while long and short vane lap lengths have less impact. Finally, we compared the internal flow distribution between the initial model and the optimized model, and found that the slit structure could effectively reduce the pressure difference between the suction side and the pressure side of the blade. By weakening the large-scale vortex in the flow path and reducing the hydraulic losses, the drainage trough impellers obtained based on orthogonal tests can significantly improve the hydraulic efficiency of low-specific speed centrifugal pumps.Item Soluble epoxide hydrolase inhibition by t-TUCB promotes brown adipogenesis and reduces serum triglycerides in diet-induced obesity(2020) Overby, Haley; Yang, Yang; Xu, Xinyun; Graham, Katherine; Hildreth, Kelsey; Choi, Sue; Wan, Debin; Morisseau, Christophe; Zeldin, Darryl C.; Hammock, Bruce D.; Wang, Shu (TTU); Bettaieb, Ahmed; Zhao, LingBrown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and sEHI in brown adipogenesis and BAT activity in treating diet-induced obesity (DIO) have not been reported. sEH expression was studied in in vitro models of brown adipogenesis and the fat tissues of DIO mice. The effects of the sEHI, trans-4-{4-[3-(4-trifluoromethoxy-phenyl)ureido]-cyclohexyloxy-benzoic acid (t-TUCB), were studied in vitro and in the obese mice via mini osmotic pump delivery. sEH expression was increased in brown adipogenesis and the BAT of the DIO mice. t-TUCB promoted brown adipogenesis in vitro. Although t-TCUB did not change body weight, fat pad weight, or glucose and insulin tolerance in the obese mice, it decreased serum triglycerides and increased protein expression of genes important for lipid metabolism in the BAT. Our results suggest that sEH may play a critical role in brown adipogenesis, and sEHI may be beneficial in improving BAT protein expression involved in lipid metabolism. Further studies using the sEHI combined with EpFA generating diets for obesity treatment and prevention are warranted.Item Two-phase flow investigation of sewage pumps with different tip clearance via computational fluid dynamics and multi-factor ANOVA(2024) Yang, Yang; Wang, Hui; Hu, Qixiang; Ji, Leilei; He, Zhaoming (TTU); Shi, Weidong; Song, Xiangyu; Zhou, LingSewage pumps are widely utilized in various applications, including municipal wastewater treatment plants, industrial processes, and residential sewage systems. These pumps are specifically designed to handle the transportation of mixtures consisting of solid and liquid components, commonly observed as two-phase flow. In this study, semi-open sewage pumps with varying clearance sizes have been examined through adjustment of the geometrical model. Multi-factor analysis of variance is employed to investigate the combined influence of different two-phase flow conditions and tip clearance sizes on the performance of sewage pumps. The results show that the performance of the pump decreases significantly as the clearance size increases. Also, the sensitivity of pump efficiency to variations in tip clearance size is contingent upon the flow rate. Under part-load conditions, both particle concentration and clearance size exhibit a notable effect on efficiency. The two-phase flow will greatly enhance the intensity of the unsteady flow near the inlet and outlet of the semi-open impeller, which is the main reason for the performance degradation of the sewage pump. The findings of this research provide valuable insights for enhancing the hydraulic performance and operational stability of semi-open sewage pumps operating under two-phase flow conditions.