Browsing by Author "Zeldin, Darryl C."
Now showing 1 - 2 of 2
- Results Per Page
- Sort Options
Item Natural products in the prevention of metabolic diseases: Lessons learned from the 20th kast frontier scientists workshop(2021) Baek, Seung J.; Hammock, Bruce D.; Hwang, In Koo; Li, Qingxiao; Moustaid-Moussa, Naima (TTU); Park, Yeonhwa; Safe, Stephen; Suh, Nanjoo; Yi, Sun Shin; Zeldin, Darryl C.; Zhong, Qixin; Bradbury, Jennifer Alyce; Edin, Matthew L.; Graves, Joan P.; Jung, Hyo Young; Jung, Young Hyun; Kim, Mi Bo; Kim, Woosuk; Lee, Jaehak; Li, Hong; Moon, Jong Seok; Yoo, Ik Dong; Yue, Yiren; Lee, Ji Young; Han, Ho JaeThe incidence of metabolic and chronic diseases including cancer, obesity, inflammation-related diseases sharply increased in the 21st century. Major underlying causes for these diseases are inflammation and oxidative stress. Accordingly, natural products and their bioactive components are obvious therapeutic agents for these diseases, given their antioxidant and anti-inflammatory properties. Research in this area has been significantly expanded to include chemical identification of these compounds using advanced analytical techniques, determining their mechanism of action, food fortification and supplement development, and enhancing their bioavailability and bioactivity using nanotechnology. These timely topics were discussed at the 20th Frontier Scientists Workshop sponsored by the Korean Academy of Science and Technology, held at the University of Hawaii at Manoa on 23 November 2019. Scientists from South Korea and the U.S. shared their recent research under the overarching theme of Bioactive Compounds, Nanoparticles, and Disease Prevention. This review summarizes presentations at the workshop to provide current knowledge of the role of natural products in the prevention and treatment of metabolic diseases.Item Soluble epoxide hydrolase inhibition by t-TUCB promotes brown adipogenesis and reduces serum triglycerides in diet-induced obesity(2020) Overby, Haley; Yang, Yang; Xu, Xinyun; Graham, Katherine; Hildreth, Kelsey; Choi, Sue; Wan, Debin; Morisseau, Christophe; Zeldin, Darryl C.; Hammock, Bruce D.; Wang, Shu (TTU); Bettaieb, Ahmed; Zhao, LingBrown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and sEHI in brown adipogenesis and BAT activity in treating diet-induced obesity (DIO) have not been reported. sEH expression was studied in in vitro models of brown adipogenesis and the fat tissues of DIO mice. The effects of the sEHI, trans-4-{4-[3-(4-trifluoromethoxy-phenyl)ureido]-cyclohexyloxy-benzoic acid (t-TUCB), were studied in vitro and in the obese mice via mini osmotic pump delivery. sEH expression was increased in brown adipogenesis and the BAT of the DIO mice. t-TUCB promoted brown adipogenesis in vitro. Although t-TCUB did not change body weight, fat pad weight, or glucose and insulin tolerance in the obese mice, it decreased serum triglycerides and increased protein expression of genes important for lipid metabolism in the BAT. Our results suggest that sEH may play a critical role in brown adipogenesis, and sEHI may be beneficial in improving BAT protein expression involved in lipid metabolism. Further studies using the sEHI combined with EpFA generating diets for obesity treatment and prevention are warranted.