A comparative genomics multitool for scientific discovery and conservation

dc.creatorGenereux, Diane P.
dc.creatorSerres, Aitor
dc.creatorArmstrong, Joel
dc.creatorJohnson, Jeremy
dc.creatorMarinescu, Voichita D.
dc.creatorMurén, Eva
dc.creatorJuan, David
dc.creatorBejerano, Gill
dc.creatorCasewell, Nicholas R.
dc.creatorChemnick, Leona G.
dc.creatorDamas, Joana
dc.creatorDi Palma, Federica
dc.creatorDiekhans, Mark
dc.creatorFiddes, Ian T.
dc.creatorGarber, Manuel
dc.creatorGladyshev, Vadim N.
dc.creatorGoodman, Linda
dc.creatorHaerty, Wilfried
dc.creatorHouck, Marlys L.
dc.creatorHubley, Robert
dc.creatorKivioja, Teemu
dc.creatorKoepfli, Klaus Peter
dc.creatorKuderna, Lukas F.K.
dc.creatorLander, Eric S.
dc.creatorMeadows, Jennifer R.S.
dc.creatorMurphy, William J.
dc.creatorNash, Will
dc.creatorNoh, Hyun Ji
dc.creatorNweeia, Martin
dc.creatorPfenning, Andreas R.
dc.creatorPollard, Katherine S.
dc.creatorRay, David A. (TTU)
dc.creatorShapiro, Beth
dc.creatorSmit, Arian F.A.
dc.creatorSpringer, Mark S.
dc.creatorSteiner, Cynthia C.
dc.creatorSwofford, Ross
dc.creatorTaipale, Jussi
dc.creatorTeeling, Emma C.
dc.creatorTurner-Maier, Jason
dc.creatorAlfoldi, Jessica
dc.creatorBirren, Bruce
dc.creatorRyder, Oliver A.
dc.creatorLewin, Harris A.
dc.creatorPaten, Benedict
dc.creatorMarques-Bonet, Tomas
dc.creatorLindblad-Toh, Kerstin
dc.creatorKarlsson, Elinor K.
dc.description© 2020, The Author(s). cc-by
dc.description.abstractThe Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
dc.identifier.citationGenereux, D.P., Serres, A., Armstrong, J., Johnson, J., Marinescu, V.D., Muren, E., Juan, D., Bejerano, G., Casewell, N.R., Chemnick, L.G., Damas, J., Di, Palma, F., Diekhans, M., Fiddes, I.T., Garber, M., Gladyshev, V.N., Goodman, L., Haerty, W., Houck, M.L., . . . Karlsson, E.K.. 2020. A comparative genomics multitool for scientific discovery and conservation. Nature, 587(7833). https://doi.org/10.1038/s41586-020-2876-6
dc.titleA comparative genomics multitool for scientific discovery and conservation


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