Photoinduced radical tandem annulation of 1,7-diynes: an approach for divergent assembly of functionalized quinolin-2(1H)-ones

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dc.creatorChen, Daixiang
dc.creatorSong, Zhi Jie
dc.creatorYan, Shenghu
dc.creatorLi, Guigen (TTU)
dc.creatorWang, Jia Yin
dc.creatorZhang, Yue
dc.date.accessioned2024-05-16T19:43:52Z
dc.date.available2024-05-16T19:43:52Z
dc.date.issued2024
dc.descriptionCopyright © 2024 Chen, Song, Yan, Li, Wang and Zhang. cc-by
dc.description.abstractThe first photocatalytic trichloromethyl radical-triggered annulative reactions of amide-linked 1,7-diynes with polyhalomethanes were established for the flexible assembly of functionalized quinolin-2(1H)-ones with generally acceptable yields. With the installation of the aryl group (R1) into the alkynyl moiety, C-center radical-initiated Kharasch-type addition/nucleophilic substitution/elimination cascade to produce quinolin-2(1H)-ones-incorporating gem-dihaloalkene, whereas three examples of polyhalogenated quinolin-2(1H)-ones were afforded when amide-linked 1,7-diynes bearing two terminal alkyne units were subjected to BrCX3 by exploiting dry acetonitrile as a solvent.
dc.identifier.citationChen, D., Song, Z.-J., Yan, S., Li, G., Wang, J.-Y., & Zhang, Y.. 2024. Photoinduced radical tandem annulation of 1,7-diynes: an approach for divergent assembly of functionalized quinolin-2(1H)-ones. Frontiers in Chemistry, 12. https://doi.org/10.3389/fchem.2024.1371978
dc.identifier.urihttps://doi.org/10.3389/fchem.2024.1371978
dc.identifier.urihttps://hdl.handle.net/2346/98139
dc.language.isoeng
dc.subject1,7-diynes
dc.subjectannulative reactions
dc.subjectKharasch addition
dc.subjectphotoinduced
dc.subjectquinolin-2(1H)-ones
dc.titlePhotoinduced radical tandem annulation of 1,7-diynes: an approach for divergent assembly of functionalized quinolin-2(1H)-ones
dc.typeArticle

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