Sex-Dependent Effects of Eicosapentaenoic Acid on Hepatic Steatosis in UCP1 Knockout Mice

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dc.creatorAlbracht-Schulte, Kembra (TTU)
dc.creatorWilson, Savanna (TTU)
dc.creatorJohnson, Paige (TTU)
dc.creatorPahlavani, Mandana (TTU)
dc.creatorRamalingam, Latha (TTU)
dc.creatorGoonapienuwala, Bimba (TTU)
dc.creatorKalupahana, Nishan S. (TTU)
dc.creatorFestuccia, William T.
dc.creatorScoggin, Shane (TTU)
dc.creatorKahathuduwa, Chanaka N. (TTUHSC)
dc.creatorMoustaid-Moussa, Naima (TTU)
dc.date.accessioned2022-03-30T20:53:59Z
dc.date.available2022-03-30T20:53:59Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en_US
dc.description.abstractVisceral obesity may be a driving factor in nonalcoholic fatty liver disease (NAFLD) development. Previous studies have shown that the omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA), ameliorates obesity in high-fat (HF) fed male, C57Bl/6 mice at thermoneutral conditions, independent of uncoupling protein 1 (UCP1). Our goals herein were to investigate sex-dependent mechanisms of EPA in the livers of wild type (WT) and UCP1 knockout (KO) male and female mice fed a HF diet (45% kcal fat; WT-HF, KO-HF) with or without supplementation of 36 g/kg EPA (WT-EPA, KO-EPA). KO significantly increased body weight in males, with no significant reductions with EPA in the WT or KO groups. In females, there were no significant differences in body weight among KO groups and no effects of EPA. In males, liver TGs were significantly higher in the KO-HF group and reduced with EPA, which was not observed in females. Accordingly, gene and protein markers of mitochondrial oxidation, peroxisomal biogenesis and oxidation, as well as metabolic futile cycles were sex-dependently impacted by KO and EPA supplementation. These findings suggest a genotypic difference in response to dietary EPA supplementation on the livers of male and female mice with diet-induced obesity and housed at thermoneutrality.en_US
dc.identifier.citationAlbracht-Schulte K, Wilson S, Johnson P, Pahlavani M, Ramalingam L, Goonapienuwala B, Kalupahana NS, Festuccia WT, Scoggin S, Kahathuduwa CN, Moustaid-Moussa N. Sex-Dependent Effects of Eicosapentaenoic Acid on Hepatic Steatosis in UCP1 Knockout Mice. Biomedicines. 2021; 9(11):1549. https://doi.org/10.3390/biomedicines9111549en_US
dc.identifier.urihttps://doi.org/10.3390/biomedicines9111549
dc.identifier.urihttps://hdl.handle.net/2346/88888
dc.language.isoengen_US
dc.subjectEicosapentaenoic Acid (EPA)en_US
dc.subjectNonalcoholic Fatty Liver Disease (NAFLD)en_US
dc.subjectObesityen_US
dc.subjectOmega-3 Polyunsaturated Fatty Acidsen_US
dc.subjectThermoneutralityen_US
dc.subjectUncoupling Protein 1 (UCP1)en_US
dc.titleSex-Dependent Effects of Eicosapentaenoic Acid on Hepatic Steatosis in UCP1 Knockout Miceen_US
dc.typeArticleen_US

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