Discordant dose-dependent metabolic effects of eicosapentanoic acid in diet-induced obese mice

Simple item page
dc.creatorPahlavani, Mandana (TTU)
dc.creatorRamalingam, Latha (TTU)
dc.creatorMiller, Emily K. (TTU)
dc.creatorDavis, Hanna (TTU)
dc.creatorScoggin, Shane (TTU)
dc.creatorMoustaid-Moussa, Naima (TTU)
dc.date.accessioned2023-04-13T20:32:44Z
dc.date.available2023-04-13T20:32:44Z
dc.date.issued2020
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. cc-by
dc.description.abstractObesity is a widespread epidemic that increases the risk for several metabolic diseases. Despite several beneficial health effects of eicosapentaenoic acid (C20:5n-3, EPA), previous studies have used very high doses of EPA. In this study, dose-dependent effects of EPA on metabolic outcomes were determined in diet-induced obese mice. We used B6 male mice, fed high-fat diet (HF, 45% kcal fat) or HF diet supplemented with 9, 18, and 36 g/kg of EPA-enriched fish oil for 14 weeks. We conducted metabolic phenotyping during the feeding period, and harvested tissues and blood at termination. Only mice fed 36 g/kg of EPA significantly (p < 0.05) lowered body weight, fat content and epididymal fat pad weight, compared to HF. Both 18 and 36 g/kg doses of EPA significantly increased glucose clearance and insulin sensitivity, compared to HF or 9 g/kg of EPA. Locomotor activity was significantly increased with both 18 and 36 g/kg doses of EPA. Interestingly, all doses of EPA compared to HF, significantly increased energy expenditure and oxygen consumption and significantly reduced serum insulin, leptin, and triglycerides levels. These results demonstrate weight-and adiposity-independent metabolic benefits of EPA, at doses comparable to those currently used to treat hypertriglyceridemia.
dc.identifier.citationPahlavani, M., Ramalingam, L., Miller, E.K., Davis, H., Scoggin, S., & Moustaid-Moussa, N.. 2020. Discordant dose-dependent metabolic effects of eicosapentanoic acid in diet-induced obese mice. Nutrients, 12(5). https://doi.org/10.3390/nu12051342
dc.identifier.urihttps://doi.org/10.3390/nu12051342
dc.identifier.urihttps://hdl.handle.net/2346/92801
dc.language.isoeng
dc.subjectDose-response
dc.subjectEicosapentaenoic acid
dc.subjectGlucose homeostasis
dc.subjectMice
dc.subjectObesity
dc.subjectOmega 3 fatty acids
dc.titleDiscordant dose-dependent metabolic effects of eicosapentanoic acid in diet-induced obese mice
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Main article with TTU Libraries cover page.pdf
Size:
2.59 MB
Format:
Adobe Portable Document Format
Download

Collections

Faculty Research