Evolutionary history of the vertebrate Piwi gene family

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dc.creatorGutierrez, Javier
dc.creatorPlatt, Roy
dc.creatorOpazo, Juan C.
dc.creatorRay, David A. (TTU)
dc.creatorHoffmann, Federico
dc.creatorVandewege, Michael
dc.date.accessioned2022-08-29T17:18:28Z
dc.date.available2022-08-29T17:18:28Z
dc.date.issued2021
dc.description© 2021 Gutierrez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.en_US
dc.description.abstractPIWIs are regulatory proteins that belong to the Argonaute family. Piwis are primarily expressed in gonads and protect the germline against the mobilization and propagation of transposable elements (TEs) through transcriptional gene silencing. Vertebrate genomes encode up to four Piwi genes: Piwil1, Piwil2, Piwil3 and Piwil4, but their duplication history is unresolved. We leveraged phylogenetics, synteny and expression analyses to address this void. Our phylogenetic analysis suggests Piwil1 and Piwil2 were retained in all vertebrate members. Piwil4 was the result of Piwil1 duplication in the ancestor of gnathostomes, but was independently lost in ray-finned fishes and birds. Further, Piwil3 was derived from a tandem Piwil1 duplication in the common ancestor of marsupial and placental mammals, but was secondarily lost in Atlantogenata (Xenarthra and Afrotheria) and some rodents. The evolutionary rate of Piwil3 is considerably faster than any Piwi among all lineages, but an explanation is lacking. Our expression analyses suggest Piwi expression has mostly been constrained to gonads throughout vertebrate evolution. Vertebrate evolution is marked by two early rounds of whole genome duplication and many multigene families are linked to these events. However, our analyses suggest Piwi expansion was independent of whole genome duplications.en_US
dc.identifier.citationGutierrez J, Platt R, Opazo JC, Ray DA, Hoffmann F, Vandewege M. 2021. Evolutionary history of the vertebrate Piwi gene family. PeerJ 9:e12451 https://doi.org/10.7717/peerj.12451en_US
dc.identifier.urihttps://doi.org/10.7717/peerj.12451
dc.identifier.urihttps://hdl.handle.net/2346/90057
dc.language.isoengen_US
dc.subjectRNAien_US
dc.subjectGene Duplicationen_US
dc.subjectArgonaute Gene Familyen_US
dc.subjectSelectionen_US
dc.subjectTranscriptomicsen_US
dc.subjectPhylogeneticsen_US
dc.subjectSyntenyen_US
dc.subjectComputational Biology and Bioinformaticsen_US
dc.subjectEvolutionary Studiesen_US
dc.subjectGeneticsen_US
dc.subjectMolecular Biologyen_US
dc.titleEvolutionary history of the vertebrate Piwi gene familyen_US
dc.typeArticleen_US

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