Ligand-promoted palladium-catalyzed β-methylene C-H arylation of primary aldehydes

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dc.creatorYang, Ke
dc.creatorLi, Zhi
dc.creatorLiu, Chong (TTU)
dc.creatorLi, Yunjian
dc.creatorHu, Qingyue
dc.creatorElsaid, Mazen (TTU)
dc.creatorLi, Bijin (TTU)
dc.creatorDas, Jayabrata
dc.creatorDang, Yanfeng
dc.creatorMaiti, Debabrata
dc.creatorGe, Haibo (TTU)
dc.date.accessioned2023-04-11T16:43:12Z
dc.date.available2023-04-11T16:43:12Z
dc.date.issued2022
dc.description© 2022 The Royal Society of Chemistry cc-by-nc
dc.description.abstractThe transient directing group (TDG) strategy allowed long awaited access to the direct β-C(sp3)-H functionalization of unmasked aliphatic aldehydes via palladium catalysis. However, the current techniques are restricted to terminal methyl functionalization, limiting their structural scopes and applicability. Herein, we report the development of a direct Pd-catalyzed methylene β-C-H arylation of linear unmasked aldehydes by using 3-amino-3-methylbutanoic acid as a TDG and 2-pyridone as an external ligand. Density functional theory calculations provided insights into the reaction mechanism and shed light on the roles of the external and transient directing ligands in the catalytic transformation.
dc.identifier.citationYang, K., Li, Z., Liu, C., Li, Y., Hu, Q., Elsaid, M., Li, B., Das, J., Dang, Y., Maiti, D., & Ge, H.. 2022. Ligand-promoted palladium-catalyzed β-methylene C-H arylation of primary aldehydes. Chemical Science, 13(20). https://doi.org/10.1039/d2sc01677j
dc.identifier.urihttps://doi.org/10.1039/d2sc01677j
dc.identifier.urihttps://hdl.handle.net/2346/92705
dc.language.isoeng
dc.titleLigand-promoted palladium-catalyzed β-methylene C-H arylation of primary aldehydes
dc.typeArticle

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