Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies

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dc.creatorRawat, Priyanka (TTUHSC)
dc.creatorSehar, Ujala (TTUHSC)
dc.creatorBisht, Jasbir (TTUHSC)
dc.creatorSelman, Ashley (TTUHSC)
dc.creatorCulberson, John (TTUHSC)
dc.creatorReddy, P. Hemachandra (TTU)
dc.date.accessioned2022-12-14T20:33:32Z
dc.date.available2022-12-14T20:33:32Z
dc.date.issued2022
dc.description© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en_US
dc.description.abstractAlzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain. These proteins are highly expressed in nerve cells and found in most tissues. Tau primarily provides stabilization to microtubules in the part of axons and dendrites. However, tau in a pathological state becomes hyperphosphorylated, causing tau dysfunction and leading to synaptic impairment and degeneration of neurons. This article presents a summary of the role of tau, phosphorylated tau (p-tau) in AD, and other tauopathies. Tauopathies, including Pick’s disease, frontotemporal dementia, corticobasal degeneration, Alzheimer’s disease, argyrophilic grain disease, progressive supranuclear palsy, and Huntington’s disease, are the result of misprocessing and accumulation of tau within the neuronal and glial cells. This article also focuses on current research on the post-translational modifications and genetics of tau, tau pathology, the role of tau in tauopathies and theen_US
dc.identifier.citationRawat P, Sehar U, Bisht J, Selman A, Culberson J, Reddy PH. Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies. International Journal of Molecular Sciences. 2022; 23(21):12841. https://doi.org/10.3390/ijms232112841en_US
dc.identifier.urihttps://doi.org/10.3390/ijms232112841
dc.identifier.urihttps://hdl.handle.net/2346/90447
dc.language.isoengen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectDementiaen_US
dc.subjectAmyloid Betaen_US
dc.subjectPhosphorylated Tauen_US
dc.subjectOxidative Stressen_US
dc.subjectTauopathyen_US
dc.titlePhosphorylated Tau in Alzheimer’s Disease and Other Tauopathiesen_US
dc.typeArticleen_US

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