The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: A systematic review with meta-analysis
dc.creator | Wang, Chao | |
dc.creator | Yang, Lu | |
dc.creator | Wang, Shu | |
dc.creator | Zhang, Zhan | |
dc.creator | Yu, Yongquan | |
dc.creator | Wang, Meilin | |
dc.creator | Cromie, Meghan (TTU) | |
dc.creator | Gao, Weimin (TTU) | |
dc.creator | Wang, Shou Lin | |
dc.date.accessioned | 2023-05-24T18:41:29Z | |
dc.date.available | 2023-05-24T18:41:29Z | |
dc.date.issued | 2016 | |
dc.description | cc-by | |
dc.description.abstract | The association between endocrine disrupting chemicals (EDCs) and human sperm quality is controversial due to the inconsistent literature findings, therefore, a systematic review with meta-analysis was performed. Through the literature search and selection based on inclusion criteria, a total of 9 studies (7 cross-sectional, 1 case-control, and 1 pilot study) were analyzed for classic EDCs (5 studies for phthalate esters and 4 studies for organochlorines). Funnel plots revealed a symmetrical distribution with no evidence of publication bias (Begg's test: intercept = 0.40; p = 0.692). The summary odds ratios (OR) of human sperm quality associated with the classic EDCs was 1.67 (95% CI: 1.31-2.02). After stratification by specific chemical class, consistent increases in the risk of abnormal sperm quality were found in phthalate ester group (OR = 1.52; 95% CI: 1.09-1.95) and organochlorine group (OR = 1.98; 95% CI: 1.34-2.62). Additionally, identification of official data, and a comprehensive review of the mechanisms were performed, and better elucidated the increased risk of these classic EDCs on abnormal sperm quality. The present systematic review and meta-analysis helps to identify the impact of classic EDCs on human sperm quality. However, it still highlights the need for additional epidemiological studies in a larger variety of geographic locations. | |
dc.identifier.citation | Wang, C., Yang, L., Wang, S., Zhang, Z., Yu, Y., Wang, M., Cromie, M., Gao, W., & Wang, S.-L.. 2016. The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: A systematic review with meta-analysis. Scientific Reports, 6. https://doi.org/10.1038/srep19982 | |
dc.identifier.uri | https://doi.org/10.1038/srep19982 | |
dc.identifier.uri | https://hdl.handle.net/2346/93670 | |
dc.language.iso | eng | |
dc.title | The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: A systematic review with meta-analysis | |
dc.type | Article |
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