Antimicrobials for Water Systems in Manned Spaceflight – Past, Present, and Future Applications and Challenges

The use of antimicrobials to control microbiological growth in manned spaceflight water-based systems has and will continue to have a unique set of challenges and needs. The challenges are varied, and include antimicrobial effectiveness, crew health and safety, materials compatibility, optimal system functionality, antimicrobial shelf life, means to monitor antimicrobial concentration, and means to re-introduce biocides periodically in the case of depletion. Needs vary from application to application, and include control of pathogens for crew health, control of biofilm formation for optimal system functionality, inhibition and prevention of microbiologically influenced corrosion, optimization of wetted metallic material life, and general living quarter and consumable aesthetics with respect to odor and taste. This paper outlines and discusses the various antimicrobials used in prior and current manned spaceflight water-based applications with focus on pros, cons and lessons learned. Design factors such as minimum inhibitory concentration, minimum lethal concentration, required circulated concentrations, materials selection, means to introduce, means to monitor real-time, and concentration maintenance are discussed. The challenges associated with longer term missions, as well as long-term system dormancy as envisioned for exploration missions, lunar habitats, and a manned Mars mission are outlined with respect to anticipated needs and potential design solutions.