Kinetic and Parametric Analysis of the Separation of Ultra-Small, Aqueous Superparamagnetic Iron Oxide Nanoparticle Suspensions under Quadrupole Magnetic Fields

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dc.creatorCiannella, Stefano (TTU)
dc.creatorWu, Xian
dc.creatorGonzález-Fernández, Cristina (TTU)
dc.creatorRezaei, Bahareh
dc.creatorStrayer, Jacob
dc.creatorChoe, Hyeon
dc.creatorWu, Kai
dc.creatorChalmers, Jeffrey
dc.creatorGomez-Pastora, Jenifer (TTU)
dc.date.accessioned2024-01-25T20:43:31Z
dc.date.available2024-01-25T20:43:31Z
dc.date.issued2023
dc.description© 2023 by the authors. cc-by
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have gathered tremendous scientific interest, especially in the biomedical field, for multiple applications, including bioseparation, drug delivery, etc. Nevertheless, their manipulation and separation with magnetic fields are challenging due to their small size. We recently reported the coupling of cooperative magnetophoresis and sedimentation using quadrupole magnets as a promising strategy to successfully promote SPION recovery from media. However, previous studies involved SPIONs dispersed in organic solvents (non-biocompatible) at high concentrations, which is detrimental to the process economy. In this work, we investigate, for the first time, the magnetic separation of 20 nm and 30 nm SPIONs dispersed in an aqueous medium at relatively low concentrations (as low as 0.5 g·L−1) using our custom, permanent magnet-based quadrupole magnetic sorter (QMS). By monitoring the SPION concentrations along the vessel within the QMS, we estimated the influence of several variables in the separation and analyzed the kinetics of the process. The results obtained can be used to shed light on the dynamics and interplay of variables that govern the fast separation of SPIONs using inexpensive permanent magnets.
dc.identifier.citationCiannella, S., Wu, X., Gonzalez-Fernandez, C., Rezaei, B., Strayer, J., Choe, H., Wu, K., Chalmers, J., & Gomez-Pastora, J.. 2023. Kinetic and Parametric Analysis of the Separation of Ultra-Small, Aqueous Superparamagnetic Iron Oxide Nanoparticle Suspensions under Quadrupole Magnetic Fields. Micromachines, 14(11). https://doi.org/10.3390/mi14112107
dc.identifier.urihttps://doi.org/10.3390/mi14112107
dc.identifier.urihttps://hdl.handle.net/2346/97544
dc.language.isoeng
dc.subjectcooperative magnetophoresis
dc.subjectkinetic modeling
dc.subjectmagnetic sedimentation
dc.subjectquadrupole magnetic sorter (QMS)
dc.subjectself-assembly
dc.subjectsuperparamagnetic iron oxide nanoparticles (SPIONs)
dc.titleKinetic and Parametric Analysis of the Separation of Ultra-Small, Aqueous Superparamagnetic Iron Oxide Nanoparticle Suspensions under Quadrupole Magnetic Fields
dc.typeArticle

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